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Научно-практическая ревматология

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Эффективность и безопасность тофацитиниба при иммуновоспалительных ревматических заболеваниях (часть I)

https://doi.org/10.14412/1995-4484-2020-62-79

Аннотация

Расшифровка механизмов патогенеза иммуновоспалительных ревматических заболеваний (ИВРЗ) в сочетании с разработкой широкого спектра генно-инженерных биологических препаратов (ГИБП) относятся к числу крупных достижений медицины XXI в. Новое перспективное направление фармакотерапии ИВРЗ связано с созданием так называемых «таргетных» пероральных лекарственных препаратов, к которым в первую очередь относятся ингибиторы Янус-киназ (JanuskinaseJAK), получившие название Якинибы (Jakinibs). Первым представителем класса ингибиторов JAK является тофацитиниб (ТОФА), который зарегистрирован для лечения ревматоидного артрита (РА), псориатического артрита и язвенного колита. В обзоре (часть I) представлены новые данные, касающиеся эффективности и безопасности ТОФА при РА, обсуждается место ТОФА в лечении РА в рамках стратегии «Лечение до достижения цели» и новых рекомендаций EULAR. В части II обзора будут представлены данные, касающиеся применения ТОФА при других ИВРЗ.

Об авторах

Е. Л. Насонов
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

Евгений Львович Насонов - научный руководитель ФГБНУ«НИИР им. В.А. Насоновой», академик РАН, профессор, доктор медицинских наук.

115522, Москва, Каширское шоссе, 34А; 119991, Москва, ул. Трубецкая, 8, стр. 2


Конфликт интересов: нет


А. С. Авдеева
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия

Научный сотрудник лаборатории стандартизации терапии ревматических заболеваний ФГБНУ «НИИР им. В.А. Насоновой», кандидат медицинских наук.

115522, Москва, Каширское шоссе, 34А


Конфликт интересов: нет


А. М. Лила
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

Директор ФГБНУ «НИИР им. В.А. Насоновой», профессор, доктор медицинских наук.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр.1


Конфликт интересов: нет


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Насонов Е.Л., Авдеева А.С., Лила А.М. Эффективность и безопасность тофацитиниба при иммуновоспалительных ревматических заболеваниях (часть I). Научно-практическая ревматология. 2020;58(1):62-79. https://doi.org/10.14412/1995-4484-2020-62-79

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Nasonov E.L., Avdeeva A.S., Lila A.M. Efficacy and safety of tofacitinib for immune-mediated inflammatory rheumatic diseases (Part I). Rheumatology Science and Practice. 2020;58(1):62-79. (In Russ.) https://doi.org/10.14412/1995-4484-2020-62-79

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)