Системная красная волчанка: история и современность
https://doi.org/10.47360/1995-4484-2022-397-412
Аннотация
Системная красная волчанка (СКВ) – системное аутоиммунное ревматическое заболевание неизвестной этиологии, характеризующееся гиперпродукцией органонеспецифических аутоантител к различным компонентам клеточного ядра и развитием иммуновоспалительного повреждения внутренних органов. В настоящее время СКВ рассматривается как прототип системной аутоиммунной патологии человека, центральным механизмом иммунопатогенеза которой является нарушение иммунологической толерантности к собственным аутоантигенам, обусловленное сложным взаимодействием генетических, эпигенетических, внешнесредовых факторов. В статье обсуждаются история учения о СКВ, вклад российских ученых (В.А. Насоновой и других) в изучение этой проблемы, современные направления клинических и научных исследований, связанные с совершенствованием критериев диагностики и фармакотерапии этого заболевания.
Ключевые слова
Об авторах
Е. Л. Насонов
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;
ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия
Россия
115522, Москва, Каширское шоссе, 34а;
119991, Москва, ул. Трубецкая, 8, стр. 2
С. К. Соловьев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
Россия
115522, Москва, Каширское шоссе, 34а
А. В. Аршинов
ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России
Россия
Россия
150000, Ярославль, ул. Революционная, 5
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Рецензия
Для цитирования:
Насонов Е.Л., Соловьев С.К., Аршинов А.В. Системная красная волчанка: история и современность. Научно-практическая ревматология. 2022;60(4):397-412. https://doi.org/10.47360/1995-4484-2022-397-412
For citation:
Nasonov E.L., Soloviev S.K., Arshinov A.V. Systemic lupus erythematosus: history and modernity. Rheumatology Science and Practice. 2022;60(4):397-412. (In Russ.) https://doi.org/10.47360/1995-4484-2022-397-412
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