NSAID-induced gastro-duodenal bleeding: risk of development and patient management
https://doi.org/10.14412/1995-4484-2008-426
Abstract
A.P. Rebrov, E.l. Koshkina, A.A. Antonyan, R.V. Lyakisheva NSAID-induced gastro-duodenal bleeding: risk of development and patient management. Retrospective analysis of gastro-duodenal bleeding (GDB) report forms was performed. Pts admitted to the department of internal diseases of Saratov regional clinical hospital from 1999 to 2004 were included. 354 cases of GDB were recorded ( 282 from 1999 to 2001 and 72 from 2002 to 2004). Cause ofbleeding, influence of NSAID administration on appearance and relapse ofbleeding, source ofbleeding and pt management were assessed. NSAJD administration was considered trigger factor of GDB in 24% in 1999-2001 and in 18% in 2002-2004. The results of the study show some tendency to decrease of NSAID- induced gastropathy frequency among causes of GDB. The main risk factors ofbleeding during NSAID treatment were age of more than 30 years, ulcer history, the first month of NSAID administration. GDB frequency did not depend on regularity of treatment and NSAID dosage.
About the Authors
A P RebrovKafedra gospital'noy terapii lechebnogo fakul'teta
E I Kashkina
Kafedra gospital'noy terapii lechebnogo fakul'teta
A A Antonyan
Kafedra gospital'noy terapii lechebnogo fakul'teta
R V Lyakisheva
Kafedra gospital'noy terapii lechebnogo fakul'teta
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Review
For citations:
Rebrov A.P., Kashkina E.I., Antonyan A.A., Lyakisheva R.V. NSAID-induced gastro-duodenal bleeding: risk of development and patient management. Rheumatology Science and Practice. 2008;46(2):13-15. (In Russ.) https://doi.org/10.14412/1995-4484-2008-426
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