Preview

Rheumatology Science and Practice

Advanced search

Primary osteoporosis prophylaxis with different calcium preparations

https://doi.org/10.14412/1995-4484-2005-554

Abstract

Objective. To assess efficacy of different modes of management in women with osteopenia. Material and methods. 190 women with osteopenia of spine and/or femoral neck aged 50 to 70 years (mean 60,6±5 years) were followed up during a year. Different modes of prophylaxis were applied. 59 pts of group 1 received Calcium D3 Nicomed 2 tablets a day, 25 pts of group 2 - Vitrum Osteomag 2 tablets a day, 46 pts of group 3 - calcium carbonate 2500 mg/day, 60 pts of control group received recommendations about diet and physical activity. Results. 3,5% from 114 pts examined had normal 25(OH)D blood level while 23% showed deficiency of vitamin D. Mean calcium consumption with milk products was 350 mg/day. Bone mineral density (BMD) significantly increased on 1,6-1% in pts older than 60 years receiving Vitrum Osteomag and Calcium D3 Nicomed respectively while younger pts did not show such changes. BMD in pts olderthan 60 years receiving calcium carbonate increased on 0,5% but this difference was not significant. Tolerability of all 3 drugs was comparable.

References

1. <div><p>Беневоленская Л.И. Общие принципы профилактики и лечения остеопороза. Консилиум, 2000, 2, 240-244.</p><p>Дедух Н.В., Бенгус Л.М., Басти А. Магний и костная ткань (Обзор литературы и собственные данные).Остеопороз и остеопатии, 2003, 1, 18-22.</p><p>Насонов Е.Л. Дефицит кальция и витамина D: новые факты и гипотезы.Остеопороз и остеопатии, 1998, 3, 42-47.</p><p>Рожинская Л.Я., Дзеранова Л.К,, Марова Е.И. и др. Применение кальция и витамина Одля профилактики остеопороза у женщин в постменопаузе. Остеопороз и остеопатии, 2001, I, 29-33.</p><p>Торопцова Н.В., Беневоленская Л.И. Профилактика остеопороза и переломов. В кн.: Рук. по остеопорозу (Ред. Л.И.Беневоленская), М., БИНОМ, 2003, 320-344.</p><p>Baksgaard L., Andersen К.P., Hyldstrup L. Calcium and vitamin D supplementation increases spinal BMD in healthy, postmenopausal women. Osteopor. Int., 1998, 8, 255-260.</p><p>Chapuy M-С., Arlot M.E., Delmas P.D., Meunier P.J. Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. Brit. Med. J., 1994, 308, 1081-1082.</p><p>Chapuy M-С., Preziosi P., Maamer М., et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteopor. Int., 1997, 7, 439-443.</p><p>Dowson-Hughes B., Dallal G.E., Kail E.A. et al. A Controlled Trial of the Effect of Calcium Supplementation on Bone Density in Postmenopausal Women. New Engl. J. Med.,1990,323 (13), 878-883.</p><p>Eddy D.M., Johnston C.C., Cummings S.R., et al. Osteoporosis: a review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis. Osteopor. Int., 1998, 8(suppl. 4),16-21.</p><p>Krall E.A., Sahyoun N., Tannenbaum S., et al. Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N. Engl. J. Med., 1989, 321, 1777-1783.</p><p>Lips P. Vitamin D deficiency and osteoporosis: the role of vitamin D deficiency and treatment with vitamin D and analogues in the prevention of osteoporosis related fractures. Eur. J. Clin. Invest., 1996, 26, 436-442.</p><p>Ooms M.E., Roos J.C., Bezemer P.D. et al. Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial. J. Clin. Endocrinol. Metab., 1995, 80, 1052-1058.</p><p>Nieves J.W, Komar L., Cosman F., Lindsay R. Benefit of calcium to antiresorptive therapy. Am.J.CIin.Nutr., 1998, 67,18-24.</p><p>Recker R.R., Hinders S., Davies K.M. et al. Correcting calcium nutritional deficiency prevents spine fracture in elderly women. J. Bone Miner. Res., 1996, 11, 1961-1966.</p><p>Reid I.R., Ames R.W., Evans M.C., et al. Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial. Am. J. Med., 1995, 98, 331-335.</p><p>Rude R.R. Magnesium deficiency: a possible risk factor for osteoporosis. In: Nutritional aspects of Osteoporosis. Eds. P.Burckhard, B. Dowson-Hughes, R.Heane. Acad. Press San Diego, San Francisco, New York, Boston, London. 2001, 263-271.</p><p>Scopacasa F., Norowitz М., Wishart J.M. et al. Calcium supplementation suppress bone resorption in early postmenopausal women. Calcif. Tissue Int., 1998, 62, 8-12.</p><p>Storm D., Eslin R., Porter E.S. et al. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial. J. Clin. Endocrinol. Metab., 1998, 83, 3817-3825.</p><p>Rossen C.J., Morrison A., Zhou H. et al. Elderly women in northern New England exibit seasonal changes in bone mineral density and calcitropic hormones. Bone Miner., 1994, 25, 83-92.</p><p>Thomas M.K., Lloyd-Jones D.M., Thadhani R.l. et al. Hypovitaminosis D in medical inpatients. N. Engl. J. Med., 1998,338, 777-783.</p></div><br />


Review

For citations:


Toroptsova N.V., Nikitinskaya O.A., Benevolenskaya L.I. Primary osteoporosis prophylaxis with different calcium preparations. Rheumatology Science and Practice. 2005;43(1):36-39. (In Russ.) https://doi.org/10.14412/1995-4484-2005-554

Views: 1046


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)