Objective. To study follow-up prognosis of subacule infectious endocarditis (IE); to reveal factors reliably influencing prognosis; to formulate approaches to its assessment. Material and methods. Retrospective study was carried out which included 98 pts relieved from the hospital with diagnosis «Subaculc 1Е». Condition of including-absence of wurgical treatment or endocarditis of prosthelis. In all pts the diagnosis was confirmed by echo-CG. In all pts the diagnosis was confirmed by Echo-CG. The prognosis of pts was followed; in dynamiacs (median term of follow up 4,8±3,7 yrs) assessment of clinical and ECG data was done. Analysis of data and forming of prognostic rule was done by database means. Results. 5-year mortality was 31%. Reasons for mortality: cardiac insufficiency (Cl) in 21 (84%), acute insufficiency of mitral valve in 4(16%) of pts. In the survived late exacerbations were: expressed Cl in 18(32%), moderate Cl in 18(32%), relapses of infectious endocarditis in 12(20%) of pts. Factors reliably influencing log-term prognosis were: IE (primary or secondare), damage of aortal valve, severe regurgitation, dimensions of left ventricle, the stage of Cl progression during acute phase and a number of other factors demonstrating informativity and proposed method of combined assessment of prognosis. Conchtsion. Cl was a basic long-term complication and reason of death; speed of its progress are determined by the combination of pointed factors. Pts from the group of high risk should have consults of cardiosurgeon prior to development of Cl.

A hs tract. Objective. Analysis of possibilities of arthrosonography of knee joints for ihe diagnosis of synovitis on early stages of gonarthritis. Material and methods. Ultrasound study of knee joints was carried out in 77 patients with gonarthritis of 1-11 Kellgren R-stage, in 12 pts X-ray symptoms of gonarthritis were absent. Study was carried out on ALOKA- 2200 (Japan) using method of two-measured tomography (В-method) with the help of linear sensor with frequency 7.5 MHz in real time. Frontal and posterior (popliteal) surfaces of knee joint were studied using longitudinal and transversal projections in lying position with maximal extension of knee joint. Results. It was found that in the group of joints with clinical synovitis the II radiologic stage of gonarthritis (58,3%) prevailed, and in the group of joints without clinical symptoms of synovitis the 1st radiological stage of gonarthritis (53%) prevailed. In the group of joints with clinical synovitis ultrasound synovitis symptoms were found in 17 joints which is 70.8% of joints with clinical synovitis (24) and 11% of total number of examined joints (154). Fluid in Ihc space of knee joints was localized prevalently over condyle of the Libia (70.8%), in 16.6% fluid was found also in b.suprapatellaris. Enlargement of synovia more than 3 mm prevalently on account of oedema was found in 79.8% whereas in the group of joints without clinical symptoms of synovitis only in 23%. In the group of joints without clinical synovitis subclinical synovitis, i.e. synovitis found in US study was revealed in 34 joints which was 26.1% of the number of joints without clinical synovitis (130) and 22% of total number of examined joints (154). Enlargement of synovia more than 3 mm in this group of joints was found in 23% joints, namely in patients with subclinical synovitis. Decrease of cartilage thickness less than 2 mm was found in great number of joints in the group of joints wilh clinical synovitis as well as in the group og joints without synovitis (95.S% and 91.5% correspondingly). Conclusion. Arthrosonography in early gonarthritis including pre-radiologieal stage is rather informative method of diagnosis of clinical and subclinical synovitis and taking it into consideration allows us to determine optimal therapy of gonarthritis.

Two clinical cases of successful applications of cyclosposrine A in pts with systemic lupus erythematosus are presented. Kev wonls: cvclosporinc A. svstcmic lupus erythematosus.

A Its trad. Abridged literature reference and clinical description of a case of 16 y/o patient with radiologieally reliable diagnosis of osteopoikilia are presented. Patient had a section of skin fibrosis in gluteal area included into the picture of osteopoikilia which for a long lime was regarded as focal scleroderma.